Mechanism of protection against the delayed neurotoxic effects of organophosphorus esters
- PMID: 1245234
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Mechanism of protection against the delayed neurotoxic effects of organophosphorus esters
Fed Proc.
1976 Jan.
Abstract
Delayed neurotoxic effects arise as a result of two distinct biochemical events: 1) inhibiton of neurotoxic esterase, and 2) 'aging' of inhibited enzyme. Protective agents undergo reaction 1 but cannot undergo 2. Reaction 2 may interfere with a normal physiological control mechanism.
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