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. 1976 Jan;35(1):73-4.

Mechanism of protection against the delayed neurotoxic effects of organophosphorus esters

M K Johnson
  • PMID: 1245234

Mechanism of protection against the delayed neurotoxic effects of organophosphorus esters

M K Johnson. Fed Proc. 1976 Jan.

Abstract

Delayed neurotoxic effects arise as a result of two distinct biochemical events: 1) inhibiton of neurotoxic esterase, and 2) 'aging' of inhibited enzyme. Protective agents undergo reaction 1 but cannot undergo 2. Reaction 2 may interfere with a normal physiological control mechanism.

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