Lower esophageal sphincter reacts against intraabdominal pressure in children with symptoms of gastroesophageal reflux
- PMID: 12452393
- DOI: 10.1023/a:1020524412847
Lower esophageal sphincter reacts against intraabdominal pressure in children with symptoms of gastroesophageal reflux
Abstract
Studies of the effect of increased intraabdominal pressure on the lower esophageal sphincter (LES) are controversial. This study aimed to verify the LES competence against extrinsic abdominal compression in children with and without symptoms of gastroesophageal reflux (GER). Eighteen children ages 6-20 months were evaluated, 11 of them with symptoms of GER (group I) and 7 without symptoms of GER (group II). Manometry of the esophagus, LES, and stomach was performed in all children who underwent extrinsic abdominal compressions of 20, 40, 60, and 80 mm Hg. The pressure gradients in the esophagus, LES, and stomach were measured. The pressure gradient showed a significant difference only in the esophagus after extrinsic abdominal compressions of 60 mm Hg [group I median (range): 7.6mm Hg (2.7-20.0) vs group II: 2.8 mm Hg (1.4-9.6), P < 0.05], and 80 mm Hg [group I median (range): 7.7 mm Hg (3.7-28.9) vs group II: 3.8 mm Hg (1.2-21.1), P < 0.05]. It was concluded that the competence of LES to contain increased intraabdominal pressure might be an important factor in the pathophysiology of GER in children.
Similar articles
-
Lower esophageal sphincter function in children with and without gastroesophageal reflux.Gastroenterology. 1976 Aug;71(2):236-41. Gastroenterology. 1976. PMID: 939384
-
Relationship between straining, transient lower esophageal sphincter relaxation, and gastroesophageal reflux in children.Am J Gastroenterol. 2001 Jul;96(7):2019-25. doi: 10.1111/j.1572-0241.2001.03936.x. Am J Gastroenterol. 2001. PMID: 11467627
-
Manometric study of lower esophageal sphincter in children with primary acid gastroesophageal reflux and acid gastroesophageal reflux secondary to food allergy.Adv Med Sci. 2008;53(2):283-92. doi: 10.2478/v10039-008-0034-8. Adv Med Sci. 2008. PMID: 18842562
-
Pathophysiology of gastroesophageal reflux. Lower esophageal sphincter dysfunction in gastroesophageal reflux disease.Gastroenterol Clin North Am. 1990 Sep;19(3):517-35. Gastroenterol Clin North Am. 1990. PMID: 2228162 Review.
-
Physiology and pathophysiology of the esophagus in childhood.Prog Pediatr Surg. 1985;18:1-13. doi: 10.1007/978-3-642-70276-1_1. Prog Pediatr Surg. 1985. PMID: 3927412 Review.
Cited by
-
Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility.J Neurogastroenterol Motil. 2022 Oct 30;28(4):589-598. doi: 10.5056/jnm21189. J Neurogastroenterol Motil. 2022. PMID: 36250366 Free PMC article.
-
Gastroesophageal reflux disease and physical activity.Sports Med. 2006;36(5):385-91. doi: 10.2165/00007256-200636050-00002. Sports Med. 2006. PMID: 16646627
-
Which Provocation Test Will Be Added to Routine High-resolution Manometry Protocol in Unexplained Dysphagia?J Neurogastroenterol Motil. 2018 Jul 30;24(3):329-330. doi: 10.5056/jnm18111. J Neurogastroenterol Motil. 2018. PMID: 29969853 Free PMC article. No abstract available.
-
General paediatric surgical provision of percutaneous endoscopic gastrostomy in a district general hospital--a 12-year experience.Ann R Coll Surg Engl. 2009 Jul;91(5):404-9. doi: 10.1308/003588409X391749. Epub 2009 Apr 2. Ann R Coll Surg Engl. 2009. PMID: 19344554 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical