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Review
. 2002 Dec;130(3):363-9.
doi: 10.1046/j.1365-2249.2002.02016.x.

Discovery of immunopotentiatory drugs: current and future strategies

J Rhodes  1
Affiliations
Review

Discovery of immunopotentiatory drugs: current and future strategies

J Rhodes. Clin Exp Immunol. 2002 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
Human toll-like receptors 1–9, expressed on dendritic cells and other APC, mediate the detection of pathogen associated molecular patterns and the up-regulation of costimulatory molecules and cytokines in response to these pathogen-associated signals. The low-molecular-weight immunopotentiatory drugs imiquimod and resiquimod signal via TLR-7 (while resiquimod can also signal via human, but not murine, TLR-8 at higher drug concentrations).
Fig. 2
Fig. 2
Activated neutrophils, which mediate the acute phase of innate immune responses, use the myeloperoxidase, hydrogen peroxide, chloride pathway to convert l-tyrosine to p-hydroxyphenylacetaldehyde which partitions to plasma membranes to forms Schiff bases with ɛ-amino groups. In separate studies the latter process has been shown to costimulate T-cells and amplify Th1 responses in the same way as the immunopotentiatory drug tucaresol.
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