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. 2002 Nov;8(11):1188-91.
doi: 10.3201/eid0811.020408.

Rationale and methods for the National Tuberculosis Genotyping and Surveillance Network

Kenneth G Castro  1 , Harold W Jaffe
Affiliations

Rationale and methods for the National Tuberculosis Genotyping and Surveillance Network

Kenneth G Castro et al. Emerg Infect Dis. 2002 Nov.

Abstract

Our understanding of tuberculosis (TB) transmission dynamics has been refined by genotyping of Mycobacterium tuberculosis strains. The National Tuberculosis Genotyping and Surveillance Network was designed and implemented to systematically evaluate the role of genotyping technology in improving TB prevention and control activities. Genotyping proved a useful adjunct to investigations of outbreaks, unusual clusters, and laboratory cross-contamination.

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References

    1. Cave MD, Eisenach KD, McDermott PF, Bates JH, Crawford JT. IS6110: Conservation of sequence in the Mycobacterium tuberculosis complex and its utilization in DNA fingerprinting. Mol Cell Probes. 1991;5:73–80. 10.1016/0890-8508(91)90040-Q - DOI - PubMed
    1. van Embden JDA, Cave MD, Crawford JT, Dale JW, Eisenach KD, Giquel B, et al. Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology. J Clin Microbiol. 1993;31:406–9. - PMC - PubMed
    1. Mazurek GH, Cave MD, Eisenach KD, Wallace RJ, Bates JH, Crawford JT. Chromosomal DNA fingerprint patterns produced with IS6110 as strain-specific markers for epidemiologic study of tuberculosis. J Clin Microbiol. 1991;29:2030–1. - PMC - PubMed
    1. Bates JH, Mitchinson DA. Geographic distribution of bacteriophage types of Mycobacterium tuberculosis. Am Rev Respir Dis. 1969;100:189–93. - PubMed
    1. Rado TA, Bates JH, Engel HW, Mankiewicz E, Murohashi T, Mizuguchi Y, et al. World Health Organization studies on bacteriophage typing of mycobacteria: subdivision of the species Mycobacterium tuberculosis. Am Rev Respir Dis. 1975;111:459–68. - PubMed

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