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Global distribution of Mycobacterium tuberculosis spoligotypes

Ingrid Filliol et al. Emerg Infect Dis. 2002 Nov.

Abstract

We present a short summary of recent observations on the global distribution of the major clades of the Mycobacterium tuberculosis complex, the causative agent of tuberculosis. This global distribution was defined by data-mining of an international spoligotyping database, SpolDB3. This database contains 11708 patterns from as many clinical isolates originating from more than 90 countries. The 11708 spoligotypes were clustered into 813 shared types. A total of 1300 orphan patterns (clinical isolates showing a unique spoligotype) were also detected.

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References

    1. Sola C, Filliol I, Guttierez CM, Mokrousov I, Vincent V, Rastogi N. Spoligotype database of Mycobacterium tuberculosis: biogeographical distribution of shared types and epidemiologic and phylogenetic perspectives. Emerg Infect Dis. 2001;7:390–6. - PMC - PubMed
    1. Kremer K, van Soolingen D, Frothingham R, Haas WH, Hermans PWM, Martin C, et al. Comparison of methods based on different molecular epidemiological markers for typing of Mycobacterium tuberculosis strains: interlaboratory study of discriminatory power and reproducibility. J Clin Microbiol. 1999;37:2607–18. - PMC - PubMed
    1. Sebban M, Mokrousov I, Rastogi N, Sola C. A data-mining approach to spacer oligonucleotide typing of Mycobacterium tuberculosis. Bioinformatics. 2002;18:235–43. 10.1093/bioinformatics/18.2.235 - DOI - PubMed
    1. Sola C, Filliol I, Legrand E, Mokrousov I, Rastogi N. Mycobacterium tuberculosis phylogeny reconstruction based on combined numerical analysis with IS1081, IS6110, VNTR and DR-based spoligotyping suggests the existence of two new phylogeographical clades. J Mol Evol. 2001;53:680–9. 10.1007/s002390010255 - DOI - PubMed
    1. van Embden JDA, Cave MD, Crawford JT, Dale JW, Eisenach KD, Gicquel B, et al. Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology. J Clin Microbiol. 1993;31:406–9. - PMC - PubMed

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