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. 2002 Dec;40(12):4466-71.
doi: 10.1128/JCM.40.12.4466-4471.2002.

M types of group a streptococcal isolates submitted to the National Centre for Streptococcus (Canada) from 1993 to 1999

Gregory J Tyrrell  1 , Marguerite Lovgren, Betty Forwick, Nancy P Hoe, James M Musser, James A Talbot
Affiliations

M types of group a streptococcal isolates submitted to the National Centre for Streptococcus (Canada) from 1993 to 1999

Gregory J Tyrrell et al. J Clin Microbiol. 2002 Dec.

Abstract

The National Centre for Streptococcus (NCS) (Canada) determined the group A streptococcal (GAS) M types of 4,760 Canadian isolates submitted between 1993 and 1999 by classic serotyping. The 10 most frequently identified M types were M1 (26.4%), M12 (9.8%), M28 (8.9%), M3 (6.8%), M4 (6.2%), M11 (4.8%), M89 (3.1%), M6 (3.0%), M2 (2.6%), and M77 (1.9%). Nontypeable isolates accounted for 15.4% of the collection. The province of Ontario submitted 51.1% of the isolates, followed by Quebec (21.2%) and Alberta (13.9%). Together, these three provinces constituted 71.3% of the Canadian population in 1996. The numbers of M types M1, M12, M28, and M3 occurred most frequently in subjects whose ages were <1 to 15 years and 25 to 45 years, as well as in the elderly (60 to 90 years). Further analysis found that the four most frequently identified M types from blood, brain, and cerebrospinal fluid were M1 (28.2%), M28 (9.2%), M12 (9.1%), and M3 (8.2%), with 13.4% of isolates being nontypeable. The four isolates from throats most frequently identified were M1 (19.5%), M12 (15.3%), M3 (8.6%), and M28 (5%) with 19.4% of isolates being nontypeable. The sic gene of a subset of M1 strains (9.5% of the M1 collection) was sequenced. Of 36 sic types identified, the four most common were sic1.01 (22.8%), sic1.02 (14.9%), sic1.135 (10.5%), and sic1.178 (9.6%). Together these four sic types further characterized nearly 60% of the M1 strains sequenced. In summary, from the years 1993 to 1999, the NCS detected 54 M types, of which 10 different M types constituted 73.5% of the collection. M1 was the most common GAS M type circulating in the Canadian population, responsible for more than a quarter of the isolates typed. The most common throat isolates differed in M-type and proportion from those of invasive isolates. Sequencing the sic gene further characterized the most common M-type serotype 1 in a fashion that may be useful for epidemiologic investigations.

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Figures

FIG. 1.
FIG. 1.
Numbers of M1, M12, M28, and M3 isolates identified from 1993 to 1999 as a function of age.
See this image and copyright information in PMC

References

    1. Anonymous. 1996. 1996 census data. Ottawa: Census Operations Division, Statistics Canada. 1996. [Online.] http://www.statcan.ca/english/census96/table1.html.
    1. Beall, B., R. R. Facklam, T. Hoenes, and B. Schwartz. 1997. Survey of emm gene sequences and T-antigen types from a systemic Streptococcus pyogenes infection isolates collected in San Francisco, California; Atlanta, Georgia; and Connecticut in 1994 and 1995. J. Clin. Microbiol. 35:1231-1235. - PMC - PubMed
    1. Beall, B., G. Gherardi, M. Lovgren, R. R. Facklam, B. A. Forwick, and G. J. Tyrrell. 2000. emm and sof gene sequence variation in relation to serological typing of opacity-factor-positive group A streptococci. Microbiology 146:1195-1209. - PubMed
    1. Bisno, A. L., and D. L. Stevens. 2000. Streptococcus pyogenes (including streptococcal toxic shock syndrome and necrotizing fasciitis), p. 2101-2117. In G. L. Mandel, J. E. Bennett, and R. Dolin (ed.), Mandell, Douglas and Bennett's principles and practice of infectious diseases. Churchill Livingstone, Philadelphia, Pa.
    1. Coleman, G., A. Tanna, A. Efstratiou, and E. T. Gaworzewska. 1993. The serotypes of Streptococcus pyogenes present in Britain during 1980-1990 and their association with disease. J. Med. Microbiol. 93:165-178. - PubMed

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