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Review
. 2002 Dec;43(12):1997-2006.
doi: 10.1194/jlr.r200015-jlr200.

Lipoprotein lipase: genetics, lipid uptake, and regulation

Martin Merkel  1 , Robert H Eckel, Ira J Goldberg
Affiliations
Free article
Review

Lipoprotein lipase: genetics, lipid uptake, and regulation

Martin Merkel et al. J Lipid Res. 2002 Dec.
Free article

Abstract

Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described.

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