Review
doi: 10.1194/jlr.r200015-jlr200.
Lipoprotein lipase: genetics, lipid uptake, and regulation
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- PMID: 12454259
- DOI: 10.1194/jlr.r200015-jlr200
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Review
Lipoprotein lipase: genetics, lipid uptake, and regulation
J Lipid Res.
2002 Dec.
Free article
Abstract
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described.
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