Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Dec;55(6):348-59.
doi: 10.1136/mp.55.6.348.

Angiogenesis in epithelian ovarian cancer

E S Bamberger  1 , C W Perrett
Affiliations
Review

Angiogenesis in epithelian ovarian cancer

E S Bamberger et al. Mol Pathol. 2002 Dec.

Abstract

Angiogenesis, the development of new blood vessels from the existing vasculature, is an essential component of solid tumour growth and metastasis. Several angiogenic factors are expressed by many tumours, suggesting that tumours promote their own vascularisation by activating the host endothelium. This review will discuss various angiogenic stimulators and inhibitors in epithelian ovarian cancer (EOC), including vascular endothelial growth factor and platelet derived endothelial cell growth factor/thymidine phosphorylase. The analysis of tumour vascularisation by microvessel density will also be discussed and the relevance of these markers of angiogenesis in the prognosis of EOC will be assessed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) Vascular endothelial growth factor (VEGF) expression in primary serous epithelian ovarian cancer (EOC); original magnification, ×100. (B) Platelet derived endothelial cell growth factor/thymidine phosphorylase expression in primary serous EOC; original magnification, ×100. (C) VEGF-C expression in primary mucinous EOC; original magnification, ×16. (D) van Willebrand factor expression in primary mucinous EOC, showing several microvessels around a blood vessel; original magnification, ×100.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Czernobilsky B. Common epithelial tumors of the ovary. Blaustein’s pathology of the female genital tract, RJ Kurman, ed. New York: Springer-Verlag, 1987.
    1. Kristensen GB, Trope C. Epithelian ovarian carcinoma. Lancet 1997;349:113–17. - PubMed
    1. Land A. Ovulation, ovulation induction and ovarian carcinoma. Ballieres Clin Obstet Gynaecol 1993;7:455. - PubMed
    1. Russell P, Bannatyne P. Surgical pathology of the ovaries, Appendix B. Edinburgh: Churchill Livingstone, 1989.
    1. Serove S, Sculy R, Sobin L. The molecular pathogenesis of ovarian cancer. In: International histological classification of tumours. No. 9: Histological typing of ovarian tumours. Geneva: World Health Organisation, 1973:46–50.

MeSH terms

Substances