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. 2002 Oct;17(6):332-8.
doi: 10.1016/s0924-9338(02)00691-0.

Early development and unstable genes in schizophrenia: preliminary results

Agnes Ayton  1 , Alex G Morris, Philip J Tyson, David Hunt, Ann M Mortimer, David Cottrell
Affiliations

Early development and unstable genes in schizophrenia: preliminary results

Agnes Ayton et al. Eur Psychiatry. 2002 Oct.

Abstract

Background: Trinucleotide repeats have been associated with schizophrenia, but the evidence, based on cross-sectional clinical information, is equivocal.

Aims: To examine the relationship between genomic CAG/CTG repeat size and premorbid development in schizophrenia.

Method: Early development and premorbid functioning of 22 patients with DSM-IV diagnosis of schizophrenia were assessed by parental interviews. Repeat expansion detection (RED) technique was used to measure genomic CAG/CTG repeat size, and PCR for CAG repeat size at the ERDA-1 and CTG 18.1 loci.

Results: There was an inverse association between CAG/CTG size and perinatal complications. Patients with speech and motor developmental delay had larger repeats. The results were not due to expansion in the ERDA-1 and CTG 18.1 genes.

Conclusions: CAG/CTG repeat expansion is associated with speech and motor developmental delay in schizophrenia. We propose that the developmental model may be useful for research into the genetics of schizophrenia.

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