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Comparative Study
. 2002 Dec 25;335(2):139-43.
doi: 10.1016/s0304-3940(02)01169-2.

Amygdaloid atrophy in frontotemporal dementia and Alzheimer's disease

M Boccardi  1 , C Pennanen, M P Laakso, C Testa, C Geroldi, H Soininen, G B Frisoni
Affiliations
Comparative Study

Amygdaloid atrophy in frontotemporal dementia and Alzheimer's disease

M Boccardi et al. Neurosci Lett. .

Abstract

Crude and corrected amygdaloid volumes were computed from magnetic resonance scans in ten patients with frontotemporal dementia (FTD), 25 patients with Alzheimer's disease (AD) and 27 controls. Amygdaloid atrophy was present in FTD (P<0.005) compared to controls, and a trend for increasing atrophy from controls, through FTD to AD (P for trend <0.00005) showed that FTD amygdaloid volumes were intermediate between controls and AD. Behavioral and Klüver-Bucy-like symptoms, characteristic of FTD, cannot be explained by amygdaloid atrophy alone.

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