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. 2002;11(3):99-111.
doi: 10.1002/mpr.128.

Distinguishing generalized anxiety disorder from major depression: prevalence and impairment from current pure and comorbid disorders in the US and Ontario

Ronald C Kessler  1 , Patricia A Berglund, David J Dewit, T Bedirhan Ustün, Philip S Wang, Hans-Ulrich Wïttchen
Affiliations

Distinguishing generalized anxiety disorder from major depression: prevalence and impairment from current pure and comorbid disorders in the US and Ontario

Ronald C Kessler et al. Int J Methods Psychiatr Res. 2002.

Abstract

Estimation of comparative disease burden in epidemiological surveys is complicated by the fact that high comorbidities exist among many chronic conditions. The easiest way to take comorbidity into consideration is to distinguish between pure and comorbid conditions and to evaluate the incremental effects of comorbid conditions in prediction equations. This approach is illustrated here in an analysis of the effects of pure and comorbid major depression (MD) and generalized anxiety disorder (GAD) on a number of different measures of role impairment in the US National Comorbidity Survey (NCS) and the Mental Health Supplement to the Ontario (Canada) Health Survey (the Supplement). Pure MD and pure GAD were found to have roughly equal independent associations with role impairments. The incremental effects of having comorbid MD and GAD were found to vary depending on the outcome under investigation. The paper closes with a discussion of the methodological complexities associated with generalizing to comorbidities that involve rare conditions or more than two disorders.

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References

    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised. Washington DC: American Psychiatric Press, 1987.
    1. Berardi D, Berti Ceroni G, Leggieri G, Rucci P, Üstün B, Ferrari G. Mental, physical and functional status in primary care attenders. Int J Psychiatry Med 1999; 29: 133–48. - PubMed
    1. Brawman‐Mintzer O, Lydiard RB, Emannuel N, Payeur R, Johnson M, Roberts J, Jarrell MP, Ballenger JC. Psychiatric comorbidity in patients with generalized anxiety disorder. Am J Psychiatry 1993; 150: 1216–18. - PubMed
    1. Brown TA, Barlow DH, Liebowitz MR. The empirical basis of generalized anxiety disorder. Am J Psychiatry 1994; 151: 1272–80. - PubMed
    1. Brown TA, Chorpita BF, Barlow DH. Structural relationships among dimensions of the DSM‐IV anxiety and mood disorders and dimensions of negative affect, positive affect, and autonomic arousal. J Abnorm Psychol 1998; 107: 179–92. - PubMed

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