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. 2002 Jul;134(1):36-8.
doi: 10.1023/a:1020600520233.

Antithrombotic activity of N,N-dichlorotaurine on mouse model of thrombosis in vivo

M A Murina  1 , O D Fesenko, V I Sergienko, N A Chudina, D I Roshchupkin
Affiliations

Antithrombotic activity of N,N-dichlorotaurine on mouse model of thrombosis in vivo

M A Murina et al. Bull Exp Biol Med. 2002 Jul.

Abstract

Intravenous injection of chloramine derivatives of amino acids and taurine reduced the mortality rate in mice with thrombosis induced by intravenous injection of ADP or collagen-epinephrine mixture. Intravenous injection of N,N-dichlorotaurine caused 50% inhibition of platelet aggregation induced by ADP and measured in the platelet-enriched plasma in vitro. The antithrombotic effect of chloramine derivatives of amino acids and taurine is related to their ability to suppress functional activity of platelets.

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