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Case Reports
. 2002 Dec;41(6):526-30.
doi: 10.1046/j.1365-2559.2002.01509.x.

Clear cell sarcoma of the stomach

P Pauwels  1 , M Debiec-Rychter, R Sciot, T Vlasveld, B den Butter, A Hagemeijer, P C W Hogendoorn
Affiliations
Case Reports

Clear cell sarcoma of the stomach

P Pauwels et al. Histopathology. 2002 Dec.

Abstract

Aim: Clear cell sarcoma is a high-grade sarcoma with morphological features resembling malignant melanoma. This tumour is reported to display a characteristic distribution pattern nearly always involving the extremities. We report the first case of clear cell sarcoma of the stomach.

Methods and results: A 30-year-old male developed a huge tumour of the stomach, which at first glance could be considered as a poorly differentiated carcinoma. Immunohistochemical and ultrastructural examinations were consistent with a diagnosis of metastatic melanoma. However, cytogenetic examination revealed a t(12;22) translocation, specific for clear cell sarcoma. This was confirmed by fluorescence in-situ hybridization.

Conclusion: Making a reliable diagnosis of clear cell sarcoma of the stomach requires cytogenetic or molecular diagnostic investigations, particularly to rule out metastatic melanoma. This diagnosis avoids an unnecessary search for a primary melanoma.

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