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Comment
. 2002 Dec;43(12):1488-92.
doi: 10.1046/j.1528-1157.2002.13002.x.

Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine

Alberto Verrotti  1 , Rita Greco, Giuseppe Latini, Guido Morgese, Francesco Chiarelli
Affiliations
Comment

Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine

Alberto Verrotti et al. Epilepsia. 2002 Dec.

Abstract

Purpose: To study the markers of bone turnover in epilepsy patients in the different stages of the pubertal growth before and after the beginning of carbamazepine (CBZ) monotherapy.

Methods: We have investigated bone turnover in 60 epilepsy patients treated with CBZ. They were stratified according to pubertal stage and compared with a control group of 60 sex- and age-matched healthy children.

Results: After 2 years of therapy, we found higher values of the serum markers of bone formation [bone alkaline phosphatase (bone ALP), osteocalcin (OC), carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of type III procollagen (PIIINP)], and of bone resorption [carboxy-terminal telopeptide of type I collagen (ICTP) and the urinary cross-linked N-telopeptides of type I collagen (NTX)] in patients than in control subjects, in presence of a normal vitamin D metabolism.

Conclusions: CBZ induces an increase of bone formation and of bone resorption that seems to be independent of the pubertal stage.

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Comment in

Comment on

  • Bone health in epilepsy.
    Sheth RD. Sheth RD. Epilepsia. 2002 Dec;43(12):1453-4. doi: 10.1046/j.1528-1157.2002.48102.x. Epilepsia. 2002. PMID: 12460244 No abstract available.

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