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Comment
. 2002 Dec 10;99(25):15840-2.
doi: 10.1073/pnas.262669499. Epub 2002 Dec 2.

T cells take aim at cancer

Drew Pardoll  1
Affiliations
Comment

T cells take aim at cancer

Drew Pardoll. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig 1.
Fig 1.
T cell recognition of cancer. In this scanning electron micrograph, a tumor-specific CD8+ killer T cell is shown in the act of recognizing a tumor cell expressing the cognate tumor antigen (arrow). Multiple other T cells not specific for any tumor antigens ignore the tumor cell. Tumor antigen recognition first involves generation of a tight junction with the tumor cell after which perforin is released to create pores in the tumor target. Granzymes released by the killer T cell can enter the cytoplasm of the tumor via these pores and activate effector caspases to induce apoptosis. (Magnification: ×5,000.)
See this image and copyright information in PMC

Comment on

References

    1. Yee C., Thompson, J. A., Byrd, D., Riddell, S. R., Roche, P., Celis, E. & Greenberg, P. D. (2002) Proc. Natl. Acad. Sci. USA 99, 16168-16173. - PMC - PubMed
    1. Dudley M. E., Wunderlich, J. R., Robbins, P. F., Yang, J. C., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Sherry, R., Restifo, N. P., Hubicki, A. M., et al. (2002) Science 298, 850-854. - PMC - PubMed
    1. Pardoll D. M. (2002) Nat. Rev. Immunol. 2, 227-238. - PubMed
    1. Boon T., Cerottini, J. C., Van den Eynde, B., van der Bruggen, P. & Van Pel, A. (1994) Annu. Rev. Immunol. 12, 337-365. - PubMed
    1. Levitsky H. I. (2000) Cancer J. 3, S281-S290. - PubMed

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