This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2002 Dec 10;99(25):15846-8.

doi: 10.1073/pnas.012686599. Epub 2002 Dec 2.

Surfing on protein folding energy landscapes

Joost W H Schymkowitz¹, Frederic Rousseau, Luis Serrano

Affiliations

PMID: 12461186
PMCID: PMC138524
DOI: 10.1073/pnas.012686599

Comment

Surfing on protein folding energy landscapes

Joost W H Schymkowitz et al. Proc Natl Acad Sci U S A. 2002.

. 2002 Dec 10;99(25):15846-8.

doi: 10.1073/pnas.012686599. Epub 2002 Dec 2.

Authors

Joost W H Schymkowitz¹, Frederic Rousseau, Luis Serrano

Affiliation

¹ European Molecular Biology Laboratory, Meyerhofstrasse 1, 69126 Heidelberg, Germany.

PMID: 12461186
PMCID: PMC138524
DOI: 10.1073/pnas.012686599

No abstract available

PubMed Disclaimer

Figures

Fig 1. — Fig 1.
Ribbon diagram of three proteins with an SH3-like fold. In color we show the φ values obtained by the “protein engineering” method. The color ranges from blue for low φ values to red for high φ values. The higher the φ value, the more folded is the particular region in the TSE.

See this image and copyright information in PMC

Comment on

Probing the folding free energy landscape of the Src-SH3 protein domain.
Shea JE, Onuchic JN, Brooks CL 3rd. Shea JE, et al. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16064-8. doi: 10.1073/pnas.242293099. Epub 2002 Nov 22. Proc Natl Acad Sci U S A. 2002. PMID: 12446834 Free PMC article.

Similar articles

Probing the folding free energy landscape of the Src-SH3 protein domain.
Shea JE, Onuchic JN, Brooks CL 3rd. Shea JE, et al. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16064-8. doi: 10.1073/pnas.242293099. Epub 2002 Nov 22. Proc Natl Acad Sci U S A. 2002. PMID: 12446834 Free PMC article.
The SH3-fold family: experimental evidence and prediction of variations in the folding pathways.
Guerois R, Serrano L. Guerois R, et al. J Mol Biol. 2000 Dec 15;304(5):967-82. doi: 10.1006/jmbi.2000.4234. J Mol Biol. 2000. PMID: 11124040
The role of backbone motions in ligand binding to the c-Src SH3 domain.
Wang C, Pawley NH, Nicholson LK. Wang C, et al. J Mol Biol. 2001 Nov 2;313(4):873-87. doi: 10.1006/jmbi.2001.5083. J Mol Biol. 2001. PMID: 11697910
Interfacial water molecules in SH3 interactions: Getting the full picture on polyproline recognition by protein-protein interaction domains.
Zafra-Ruano A, Luque I. Zafra-Ruano A, et al. FEBS Lett. 2012 Aug 14;586(17):2619-30. doi: 10.1016/j.febslet.2012.04.057. Epub 2012 May 11. FEBS Lett. 2012. PMID: 22584053 Review.
Folding and binding cascades: shifts in energy landscapes.
Tsai CJ, Ma B, Nussinov R. Tsai CJ, et al. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):9970-2. doi: 10.1073/pnas.96.18.9970. Proc Natl Acad Sci U S A. 1999. PMID: 10468538 Free PMC article. Review. No abstract available.

See all similar articles

Cited by

Simulation of the folding equilibrium of alpha-helical peptides: a comparison of the generalized Born approximation with explicit solvent.
Nymeyer H, García AE. Nymeyer H, et al. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13934-9. doi: 10.1073/pnas.2232868100. Epub 2003 Nov 14. Proc Natl Acad Sci U S A. 2003. PMID: 14617775 Free PMC article.
Predicting interacting hotspots for nanobodies' binding using triplets of residues.
Hamdani R, Cianferoni D, Reche R, Delgado J, Serrano L. Hamdani R, et al. Protein Sci. 2025 Aug;34(8):e70220. doi: 10.1002/pro.70220. Protein Sci. 2025. PMID: 40671551 Free PMC article.
Formation of the folding nucleus of an SH3 domain investigated by loosely coupled molecular dynamics simulations.
Settanni G, Gsponer J, Caflisch A. Settanni G, et al. Biophys J. 2004 Mar;86(3):1691-701. doi: 10.1016/S0006-3495(04)74238-1. Biophys J. 2004. PMID: 14990497 Free PMC article.

References

1. Bryngelson J. D., Onuchic, J. N., Socci, N. D. & Wolynes, P. G. (1995) Proteins Struct. Funct. Genet. 21, 167-195. - PubMed
1. Wolynes P. G., Onuchic, J. N. & Thirumalai, D. (1995) Science 267, 1619-1620. - PubMed
1. Shea J.-E., Onuchic, J. N. & Brooks, C. L., III (2002) Proc. Natl. Acad. Sci. USA 99, 16064-16068. - PMC - PubMed
1. Levinthal C. (1968) J. Chim. Phys. 65, 44-45.
1. Wetlaufer D. B. (1973) Proc. Natl. Acad. Sci. USA 70, 697-701. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources