Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jan;33(1):25-32.
doi: 10.1038/ng1058. Epub 2002 Dec 2.

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats

Peter Olofsson  1 , Jens Holmberg, Jesper Tordsson, Shemin Lu, Bo Akerström, Rikard Holmdahl
Affiliations

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats

Peter Olofsson et al. Nat Genet. 2003 Jan.

Abstract

The identification of genes underlying quantitative-trait loci (QTL) for complex diseases, such as rheumatoid arthritis, is a challenging and difficult task for the human genome project. Through positional cloning of the Pia4 QTL in rats, we found that a naturally occurring polymorphism of Ncf1 (encoding neutrophil cytosolic factor 1, a component of the NADPH oxidase complex) regulates arthritis severity. The disease-related allele of Ncf1 has reduced oxidative burst response and promotes activation of arthritogenic T cells. Pharmacological treatment with substances that activate the NADPH oxidase complex is shown to ameliorate arthritis. Hence, Ncf1 is associated with a new autoimmune mechanism leading to severe destructive arthritis, notably similar to rheumatoid arthritis in humans.

PubMed Disclaimer

MeSH terms