Review
doi: 10.1038/nri957.
A blast from the past: clearance of apoptotic cells regulates immune responses
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- PMID: 12461569
- DOI: 10.1038/nri957
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Review
A blast from the past: clearance of apoptotic cells regulates immune responses
Nat Rev Immunol.
2002 Dec.
Abstract
Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future.
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