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. 2002 Sep;29(3):281-6.
doi: 10.1023/a:1020402410522.

Cloning, expression and characterization of a novel human VMP gene

Chao Cheng, Jian Xu, Xin Ye, Jianfeng Dai, Qihan Wu, Li Zeng, Liu Wang, Wei Zhao, Chaoneng Ji, Shaohua Gu, Yi Xie, Yumin Mao

Cloning, expression and characterization of a novel human VMP gene

Chao Cheng et al. Mol Biol Rep. 2002 Sep.

Abstract

We report here cloning and characterization of a novel human gene, termed VMP, which is a vesicular membrane protein. RT-PCR analysis shows that VMP is expressed exclusively in brain of the 16 tissues examined, suggesting that it is a neuron-specific membrane protein. The cDNA encodes 195 amino acid with a putative molecular weight of about 24 KDa. VMP contains two putative membrane spanning domains and a hydrophilic tail homologous to the microtubule-binding domain of MAPs. So it is speculated that VMP may associated with microtubules through its C-terminal and plays an important role in vesicular organelles transport and nerve signals.

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