Review
Thalidomide in ankylosing spondylitis
Affiliations
- PMID: 12463469
Item in Clipboard
Review
Thalidomide in ankylosing spondylitis
Clin Exp Rheumatol.
2002 Nov-Dec.
Abstract
Despite potential side effects dominated by teratogenicity and peripheral neuropathy, thalidomide has recently been used to treat severe ankylosing spondylitis (AS). Over 50 patients have been treated across several 6-12 month open studies. Altogether 68% of the patients improved and the drop-out rate was 19%. Inhibition of NF-kappaB and/or TNFalpha is a putative mechanism for thalidomide efficacy in AS.
Similar articles
-
[The efficacy and safety of long-term thalidomide in the treatment of ankylosing spondylitis].Zhonghua Nei Ke Za Zhi. 2010 Aug;49(8):667-70. Zhonghua Nei Ke Za Zhi. 2010. PMID: 20979785 Clinical Trial. Chinese.
-
One-year open-label trial of thalidomide in ankylosing spondylitis.Arthritis Rheum. 2002 Jun 15;47(3):249-54. doi: 10.1002/art.10396. Arthritis Rheum. 2002. PMID: 12115153 Clinical Trial.
-
Understanding the role of tumor necrosis factor inhibition in ankylosing spondylitis.Semin Arthritis Rheum. 2005 Feb;34(4):668-77. doi: 10.1016/j.semarthrit.2004.08.005. Semin Arthritis Rheum. 2005. PMID: 15692960 Review.
-
Thalidomide for severe refractory ankylosing spondylitis: a 6-month open-label trial.J Rheumatol. 2003 Dec;30(12):2627-31. J Rheumatol. 2003. PMID: 14719205 Clinical Trial.
-
[Current therapy with TNFalpha blocking agents for ankylosing spondylitis and undifferentiated spondyloarthritis].Z Rheumatol. 2004 Jun;63(3):203-10. doi: 10.1007/s00393-004-0630-3. Z Rheumatol. 2004. PMID: 15224223 Review. German.
Cited by
-
Cause analysis of conversion to biologics in spondyloarthritis patients with poor response to conventional treatment.Clin Rheumatol. 2023 Dec;42(12):3251-3255. doi: 10.1007/s10067-023-06724-3. Epub 2023 Sep 23. Clin Rheumatol. 2023. PMID: 37740841
-
Adalimumab in ankylosing spondylitis: an evidence-based review of its place in therapy.Core Evid. 2008 Jul 31;2(4):295-305. Core Evid. 2008. PMID: 21221193 Free PMC article.
-
Thalidomide reduces recurrence of ankylosing spondylitis in patients following discontinuation of etanercept.Rheumatol Int. 2013 Jun;33(6):1409-13. doi: 10.1007/s00296-012-2571-5. Epub 2012 Nov 11. Rheumatol Int. 2013. PMID: 23143621 Clinical Trial.
-
Treatment of ankylosing spondylitis: focus on etanercept.Biologics. 2007 Mar;1(1):45-51. Biologics. 2007. PMID: 19707347 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials