doi: 10.1038/259095a0.
Presence of gene for beta globin in homozygous beta0 thalassaemia
- PMID: 1246358
- DOI: 10.1038/259095a0
Item in Clipboard
Presence of gene for beta globin in homozygous beta0 thalassaemia
Nature.
.
Abstract
In one southern Italian and one Pakistani patient with homozygous beta0 thalassaemia in which no detectable beta-globin synthesis occurs and no beta-globin messenger RNA is found, the gene for beta globin has been shown to be present using complementary DNA. This demonstrates that for these patients the imbalance in chain synthesis is not attributable to a gene deletion.
Similar articles
-
The severe form of alpha thalassaemia is caused by a haemoglobin gene deletion.Nature. 1974 Oct 4;251(5474):389-92. doi: 10.1038/251389a0. Nature. 1974. PMID: 4138824 No abstract available.
-
Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis).Nature. 1974 Oct 4;251(5474):392-3. doi: 10.1038/251392a0. Nature. 1974. PMID: 4424635 No abstract available.
-
Abnormal or absent beta mRNA in betao Ferrara and gene deletion in delta beta thalassaemia.Nature. 1976 Oct 7;263(5577):471-5. doi: 10.1038/263471a0. Nature. 1976. PMID: 985635
-
The molecular basis of thalassemia.CRC Crit Rev Biochem. 1974;2(3):311-42. doi: 10.3109/10409237409105450. CRC Crit Rev Biochem. 1974. PMID: 4613537 Review. No abstract available.
-
Molecular pathology of the thalassemias.Adv Intern Med. 1976;21:97-128. Adv Intern Med. 1976. PMID: 766595 Review. No abstract available.
Cited by
-
Heterogeneity in beta 0 thalassemia from Algeria: genetic, clinical and molecular studies.Hum Genet. 1980;54(2):251-7. doi: 10.1007/BF00278980. Hum Genet. 1980. PMID: 6156118
-
Organization of the chorion genes of Bombyx mori, a multigene family. I. Evidence for linkage to chromosome 2.Genetics. 1978 Oct;90(2):291-310. doi: 10.1093/genetics/90.2.291. Genetics. 1978. PMID: 730049 Free PMC article.
-
Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia.Proc Natl Acad Sci U S A. 1979 May;76(5):2400-4. doi: 10.1073/pnas.76.5.2400. Proc Natl Acad Sci U S A. 1979. PMID: 287080 Free PMC article.
-
The molecular basis of disorders of human hemoglobin synthesis.Mol Cell Biochem. 1980 Aug 16;31(3):133-45. doi: 10.1007/BF00225847. Mol Cell Biochem. 1980. PMID: 6255309 Review.
-
Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders.Proc Natl Acad Sci U S A. 1978 Mar;75(3):1222-6. doi: 10.1073/pnas.75.3.1222. Proc Natl Acad Sci U S A. 1978. PMID: 274714 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
