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Review
. 2002 Oct;12(5):648-53.
doi: 10.1016/s0959-440x(02)00366-4.

Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical "footprinting"

Michael Brenowitz  1 , Mark R Chance, Gauri Dhavan, Keiji Takamoto
Affiliations
Review

Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical "footprinting"

Michael Brenowitz et al. Curr Opin Struct Biol. 2002 Oct.

Abstract

For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.

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