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. 2002 Dec 12;4(25):4387-90.
doi: 10.1021/ol026923b.

UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species

Tsutomu Agatsuma  1 , Tsutomu Akama, Shinji Nara, Shigeki Matsumiya, Ryuichiro Nakai, Harumi Ogawa, Shizuo Otaki, Shun-Ichi Ikeda, Yutaka Saitoh, Yutaka Kanda
Affiliations

UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species

Tsutomu Agatsuma et al. Org Lett. .

Abstract

[structure: see text] UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures and stereochemistry were elucidated by a combination of two-dimensional NMR and X-ray crystallographic analysis. UCS1025A showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and antiproliferative activity against human tumor cell lines.

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