Movement-related neuronal activity reflecting the transformation of coordinates in the ventral premotor cortex of monkeys

Abstract

We examined how the transformation of coordinates from visual to motor space is reflected by neuronal activity in the ventral premotor cortex (PMv) of monkeys. Three monkeys were trained to reach with their right hand for a target that appeared on a screen. While performing the task, the monkeys wore prisms that shifted the image of the target 10 degrees, left or right, or wore no prisms, for a block of 200 trials. The nine targets were located in the same positions in visual space regardless of whether the prisms were present. Wearing the prisms required the monkeys to initiate a movement in a direction that was different from the apparent target location. Thus using the prisms, we could dissociate visual space from motor space. While the monkey performed the behavioral task, we recorded neuronal activity in the left PMv and primary motor cortex (MI), and various kinds of task-related neuronal activity were found in the motor areas. These included neurons that changed their activity during a reaction time (RT) period (the period between target presentation and movement onset), which were called "movement-related neurons" and selected for analysis. In these neurons, activity during a movement time (MT) period was also compared. Using general linear models for our statistical analysis, the neurons were then classified into four types: those whose activity was consistently dependent on location of targets in the visual coordinates regardless of whether the prisms were present or absent (V type); those that were consistently dependent on target location in the motor coordinates only; those that had different activity for both of the motor and visual coordinates; and those that had nondifferential activity for the two types of coordinates. The proportion of the four types of the neurons differed significantly between the PMv and MI. Most remarkably, neurons with V-type activity were almost exclusively recorded in the PMv and were almost exclusively found during the RT period. Such activity was never observed in an electromyogram of the working forelimb. Based on these observations, we postulate that the V and other types may represent the various intermediate stages of the transformation of coordinates and that the PMv plays a crucial role in transforming coordinates from visual to motor space.