Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2002 Dec 5;420(6915):586-90.
doi: 10.1038/nature01270.

A gene expression map of human chromosome 21 orthologues in the mouse

Affiliations
Comparative Study

A gene expression map of human chromosome 21 orthologues in the mouse

Yorick Gitton et al. Nature. .

Abstract

The DNA sequence of human chromosome 21 (HSA21) has opened the route for a systematic molecular characterization of all of its genes. Trisomy 21 is associated with Down's syndrome, the most common genetic cause of mental retardation in humans. The phenotype includes various organ dysmorphies, stereotypic craniofacial anomalies and brain malformations. Molecular analysis of congenital aneuploidies poses a particular challenge because the aneuploid region contains many protein-coding genes whose function is unknown. One essential step towards understanding their function is to analyse mRNA expression patterns at key stages of organism development. Seminal works in flies, frogs and mice showed that genes whose expression is restricted spatially and/or temporally are often linked with specific ontogenic processes. Here we describe expression profiles of mouse orthologues to HSA21 genes by a combination of large-scale mRNA in situ hybridization at critical stages of embryonic and brain development and in silico (computed) mining of expressed sequence tags. This chromosome-scale expression annotation associates many of the genes tested with a potential biological role and suggests candidates for the pathogenesis of Down's syndrome.

PubMed Disclaimer

Comment in

  • Mining the mouse genome.
    Bradley A. Bradley A. Nature. 2002 Dec 5;420(6915):512-4. doi: 10.1038/420512a. Nature. 2002. PMID: 12466846 No abstract available.
  • Functional genomics: a time and place for every gene.
    Reeves RH. Reeves RH. Nature. 2002 Dec 5;420(6915):518-9. doi: 10.1038/420518a. Nature. 2002. PMID: 12466849 No abstract available.
  • The master mammal.
    Sands AT. Sands AT. Nat Biotechnol. 2003 Jan;21(1):31-2. doi: 10.1038/nbt0103-31. Nat Biotechnol. 2003. PMID: 12511904 No abstract available.

Publication types

LinkOut - more resources