RORalpha: an orphan nuclear receptor on a high-cholesterol diet
- PMID: 12467566
- DOI: 10.1016/s0969-2126(02)00916-4
RORalpha: an orphan nuclear receptor on a high-cholesterol diet
Abstract
A high-resolution X-ray crystal structure of the retinoic acid receptor-related orphan receptor (RORalpha; NR1F1), which reveals a molecule of cholesterol within the ligand binding pocket, is a breakthrough in functional analysis of this orphan nuclear receptor.
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