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Review
. 2002 Oct;4(12):1259-64.
doi: 10.1016/s1286-4579(02)01654-4.

Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis

Abderrazzaq Belaaouaj  1
Affiliations
Free article
Review

Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis

Abderrazzaq Belaaouaj. Microbes Infect. 2002 Oct.
Free article

Abstract

Engineering of mice deficient in neutrophil elastase (NE) has allowed us to demonstrate the role of this protease in host defense against bacteria and to begin to understand its killing mechanism. Strategies to inhibit NE because of its involvement in tissue-destructive diseases should be reconsidered, while preserving its beneficial properties.

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