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Review
. 2002 Jun;22(3):259-67.
doi: 10.1023/a:1020763716886.

Participation of CaMKII in neuronal plasticity and memory formation

Martín Cammarota  1 , Lia R M Bevilaqua, Haydée Viola, Daniel S Kerr, Bruno Reichmann, Viviane Teixeira, Mário Bulla, Iván Izquierdo, Jorge H Medina
Affiliations
Review

Participation of CaMKII in neuronal plasticity and memory formation

Martín Cammarota et al. Cell Mol Neurobiol. 2002 Jun.

Abstract

1. The unique biochemical properties of Ca(2+)/calmodulin (CaM)-dependent protein kinase II have made this enzyme one of the paradigmatic models of the forever searched "memory molecule." 2. In particular, the central participation of CaMKII as a sensor of the Ca(2+) signals generated by activation of NMDA receptors after the induction of long-term plastic changes, has encouraged the use of pharmacological, genetic, biochemical, and imaging tools to unveil the role of this kinase in the acquisition, consolidation, and expression of different types of memories. 3. Here we review some of the more exciting discoveries related to the mechanisms involved in CaMKII activation and synaptic plasticity.

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References

    1. Allison, D., Chervin, A., Gelfand, V., and Craig, A. (2000). Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: Maintenance of core components independent of actin filaments and microtubules. J. Neurosci.20:4545–4554. - PMC - PubMed
    1. Barria, A., Derkach, V., and Soderling, T. (1997a). Identification of the Ca2C/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type glutamate receptor. J. Biol. Chem.272:32727–32730. - PubMed
    1. Barria, A., Muller, D., Derkach, V., Griffith, L., and Soderling, T. (1997b). Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science276:2042–2045. - PubMed
    1. Bayer, K., De Koninck, P., Leonard, A., Hell, J., and Schulman, H. (2001). Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature411:801–805. - PubMed
    1. Braun, A., and Schulman, H. (1995). The multifunctional Cap2C/calmodulin-dependent protein kinase: From form to function. Annu. Rev. Physiol.57:417–4452. - PubMed

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