Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975;27(1):45-8.
doi: 10.1007/BF00283502.

HL-A frequencies in Down's syndrome

D J Segal, J W Schlaut, H F Pabst, E E McCoy, J B Dossetor

HL-A frequencies in Down's syndrome

D J Segal et al. Humangenetik. 1975.

Abstract

HL-A antigen frequencies were examined in 76 Down's syndrome individuals and 733 normal Caucasians. 10 antigens of the first locus and 15 antigens of the second locus were defined, using a microlymphocytotoxicity technique. No significant differences were observed between the normal and Down's syndrome samples, in contrast to a previous report (Boxer and Yokoyama, 1972) of decreased HL-A antigen frequencies in Down's syndrome individuals. Our results therefore suggest that there is no relationship between trisomy 21-associated immune aberrations and altered HL-A antigen frequencies.

PubMed Disclaimer

References

    1. Science. 1973 Feb 16;179(4074):691-3 - PubMed
    1. Lancet. 1972 Dec 30;2(7792):1381-5 - PubMed
    1. Am J Med. 1972 Aug;53(2):203-18 - PubMed
    1. N Engl J Med. 1973 Apr 5;288(14):704-6 - PubMed
    1. Am J Hum Genet. 1971 Jan;23(1):67-86 - PubMed

Publication types

LinkOut - more resources