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Comparative Study
. 2002 Dec;56(6):642-4.
doi: 10.1046/j.1365-3083.2002.01174.x.

Neutralization titres and vertical HIV-1 transmission

V Bongertz  1 , C I Costa, V G Veloso, B Grinsztejn, E C J Filho, G Calvet, J H Pilotto
Affiliations
Free article
Comparative Study

Neutralization titres and vertical HIV-1 transmission

V Bongertz et al. Scand J Immunol. 2002 Dec.
Free article

Abstract

Replication of the human immunodeficiency virus type 1 (HIV-1) isolate MN in CEM cells was less neutralized by the plasma from the mothers of infected children (MIC) in comparison with the plasma from the mothers of uninfected children (MUC). Significantly higher neutralization titres were observed for the sera from MUCs compared with MICs, and only the sera from MUC showed 100% neutralization of the HIV-1 MN strain. We suggest that a simple neutralization assay as described here could be useful in prognostic analyses.

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