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Clinical Trial
. 2002 Dec;8(6):532-3.
doi: 10.1191/1352458502ms849xx.

The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study

N F Kalkers  1 , F Barkhof, E Bergers, R van Schijndel, C H Polman
Affiliations
Clinical Trial

The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study

N F Kalkers et al. Mult Scler. 2002 Dec.

Abstract

Progressive axonal loss is the most likely pathologic correlate of irreversible neurologic impairment in primary progressive multiple sclerosis. In a run-in versus treatment trial, we show that the neuroprotective agent riluzole seems to reduce the rate of cervical cord atrophy and the development of hypointense T1 brain lesions on magnetic resonance imaging.

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