doi: 10.1016/0005-2736(76)90356-4.
The inhibitor effect of probencid and structural analogues on organic anions and chloride permeabilities in ox erythrocytes
- PMID: 1247557
- DOI: 10.1016/0005-2736(76)90356-4
Item in Clipboard
The inhibitor effect of probencid and structural analogues on organic anions and chloride permeabilities in ox erythrocytes
Biochim Biophys Acta.
.
Abstract
Probenecid inhibits anion movements (organic anions and chloride) in ox erythrocytes. The I50 is 4. 10(-5) M. Structural analogues such as carinamide, p-carboxybenzene sulfonamide and p-carboxy N,N-diethyl benzene sulfonamide, which are drugs of the sulfonamide class, were also found to inhibit anion transport. These results reinforce the previously discussed view based on structural considerations, that sulfonamides act on the red cell membrane as competitors of anion transport. It is possible that probenecid and carinamide act in a similar way in the kidney.
Similar articles
-
The role of carbonic anhydrase inhibitors on anion permeability into ox red blood cells.J Physiol. 1976 Mar;256(1):61-80. doi: 10.1113/jphysiol.1976.sp011311. J Physiol. 1976. PMID: 933067 Free PMC article.
-
Effect of probenecid on the transport of methyl mercury in erythrocytes by the organic anion transport system.Arch Toxicol. 1997;71(4):218-22. doi: 10.1007/s002040050379. Arch Toxicol. 1997. PMID: 9101037
-
[Transmembrane exchange of C1- and HCO3- in erythrocytes: direct action of carbonic anhydrase inhibitors on the transport mechanism].C R Acad Hebd Seances Acad Sci D. 1975 Mar 3;280(9):1119-22. C R Acad Hebd Seances Acad Sci D. 1975. PMID: 811383 French.
-
Chloride-bicarbonate exchange and related transport processes.Biochim Biophys Acta. 1982 Dec;694(4):353-74. doi: 10.1016/0304-4157(82)90002-8. Biochim Biophys Acta. 1982. PMID: 6760896 Review. No abstract available.
-
The physiology of anion transport in red cells.Prog Hematol. 1986;14:1-21. Prog Hematol. 1986. PMID: 2418461 Review. No abstract available.
Cited by
-
Photosynthesis and the intracellular inorganic carbon pool in the bluegreen alga Anabaena variabilis: Response to external CO2 concentration.Planta. 1980 Aug;149(3):219-26. doi: 10.1007/BF00384557. Planta. 1980. PMID: 24306290
-
Evidence for control of serotonin secretion from human platelets by hydroxyl ion transport and osmotic lysis.Proc Natl Acad Sci U S A. 1977 Dec;74(12):5295-9. doi: 10.1073/pnas.74.12.5295. Proc Natl Acad Sci U S A. 1977. PMID: 23532 Free PMC article.
-
Reabsorption of monocarboxylic acids in the proximal tubule of the rat kidney. I. Transport kinetics of D-lactate, Na+-dependence, pH-dependence and effect of inhibitors.Pflugers Arch. 1982 Nov 11;395(3):212-9. doi: 10.1007/BF00584812. Pflugers Arch. 1982. PMID: 7155794 No abstract available.
-
Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles.J Clin Invest. 1985 Apr;75(4):1256-63. doi: 10.1172/JCI111824. J Clin Invest. 1985. PMID: 2985654 Free PMC article.
-
Role of anions in parathyroid hormone release from dispersed bovine parathyroid cells.Proc Natl Acad Sci U S A. 1978 Feb;75(2):876-80. doi: 10.1073/pnas.75.2.876. Proc Natl Acad Sci U S A. 1978. PMID: 24845 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
