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Clinical Trial
. 2003 Jan 15;206(1):23-6.
doi: 10.1016/s0022-510x(02)00319-2.

Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease

J Casademont  1 , O Miró, B Rodriguez-Santiago, P Viedma, R Blesa, F Cardellach
Affiliations
Clinical Trial

Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease

J Casademont et al. J Neurol Sci. .

Abstract

Electron transport chain (ETC) dysfunction has been claimed to contribute to the expression of neurodegenerative disorders. We have investigated the effects of the treatment with rivastigmine, a commonly used cholinesterase inhibitor, on lymphocyte mitochondria of patients with Alzheimer's disease (AD). Increased enzymatic activities of diverse complexes and oxidative capacity of the ETC were found. Enhanced mitochondrial ETC function may contribute to the beneficial effects of rivastigmine on clinical manifestations of AD.

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