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. 2002 Dec 15;139(2):199-203.
doi: 10.1016/s0165-3806(02)00550-3.

Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor

Patricia Laplante  1 , Josie Diorio, Michael J Meaney
Affiliations

Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor

Patricia Laplante et al. Brain Res Dev Brain Res. .

Abstract

Glucocorticoid receptor expression in primary hippocampal cell cultures was significantly increased with either 10 mM 8-bromo cAMP, 50 nM 5-carboxamidotryptamine (5-CT), a potent 5-HT7 receptor agonist, or 100 nM 5-HT. The effect of 5-HT or 5-CT was blocked with methiothepin or by a protein kinase A inhibitor, but not pindolol. These results suggest that the effects of 5-HT on hippocampal GR expression is mediated by a 5-HT7 receptor.

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