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. 2002 Nov:973:26-30.
doi: 10.1111/j.1749-6632.2002.tb04601.x.

The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion

Thierry Fournier  1 , Laetitia Pavan, Anne Tarrade, Kristina Schoonjans, Johan Auwerx, Cecile Rochette-Egly, Daniele Evain-Brion
Affiliations

The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion

Thierry Fournier et al. Ann N Y Acad Sci. 2002 Nov.

Abstract

PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that PPAR-gamma agonists inhibit EVCT invasion, whereas PPAR-gamma or pan-RXR antagonists promoted EVCT invasion by themselves and abolished PPAR-gamma agonist-mediated effect. Together these data underscore an important function of PPAR/RXR heterodimers in the modulation of trophoblast invasion.

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