Comment
doi: 10.1084/jem.20021915.
O-acetylation of GD3: an enigmatic modification regulating apoptosis?
Affiliations
- PMID: 12486095
- PMCID: PMC2196069
- DOI: 10.1084/jem.20021915
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Comment
O-acetylation of GD3: an enigmatic modification regulating apoptosis?
J Exp Med.
.
No abstract available
Figures
Subcellular compartments potentially involved in the biosynthesis, trafficking, and turnover of GD3 and AcGD3 are shown. Complexities involving 7- versus 9-AcGD3, and the possible action of O-acetylesterases are omitted. Various pathways for GD3-induced apoptosis are indicated, especially in relation to the proposed production and translocation of GD3 to mitochondrial membranes. Some of the unresolved topological issues are emphasized. Topological issues regarding ASM are not shown. See text for further discussion.
Comment on
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Acetylation suppresses the proapoptotic activity of GD3 ganglioside.J Exp Med. 2002 Dec 16;196(12):1535-41. doi: 10.1084/jem.20020960. J Exp Med. 2002. PMID: 12486096 Free PMC article.
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