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Comment
. 2002 Dec 16;196(12):1529-33.
doi: 10.1084/jem.20021915.

O-acetylation of GD3: an enigmatic modification regulating apoptosis?

Helen Y Chen  1 , Ajit Varki
Affiliations
Comment

O-acetylation of GD3: an enigmatic modification regulating apoptosis?

Helen Y Chen et al. J Exp Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Subcellular compartments potentially involved in the biosynthesis, trafficking, and turnover of GD3 and AcGD3 are shown. Complexities involving 7- versus 9-AcGD3, and the possible action of O-acetylesterases are omitted. Various pathways for GD3-induced apoptosis are indicated, especially in relation to the proposed production and translocation of GD3 to mitochondrial membranes. Some of the unresolved topological issues are emphasized. Topological issues regarding ASM are not shown. See text for further discussion.
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