doi: 10.3181/00379727-149-38749.
The anti-inflammatory actions of tilorone hydrochloride
- PMID: 124872
- DOI: 10.3181/00379727-149-38749
Item in Clipboard
The anti-inflammatory actions of tilorone hydrochloride
Proc Soc Exp Biol Med.
1975 May.
Abstract
Tilorone suppressed inflammation induced by immune (direct passive Arthus reaction) as well as by non-immune agents (carrageenam-induced paw edema and abscess formation), if the compound is given 24 hr prior to the proinflammatory agonists. The non-immune anti-inflammatory effect is independent of the adrenals. A surprising findings was that total serum hemolytic complement is markedly elevated 24 hr after a single dose of tilorone.
Similar articles
-
The interaction of tilorone and RMI 9563DA with the complement system.Int J Immunopharmacol. 1982;4(1):67-72. doi: 10.1016/0192-0561(82)90010-8. Int J Immunopharmacol. 1982. PMID: 7085140
-
Dissociation between antiinflammatory action of tilorone and its interferon inducing activity.Agents Actions. 1991 Jul;33(3-4):229-32. doi: 10.1007/BF01986567. Agents Actions. 1991. PMID: 1719782
-
Mechanism of action of colchicine. III. Antiinflammatory effects of colchicine compared with phenylbutazone and indomethacin.Arthritis Rheum. 1975 Sep-Oct;18(5):493-6. doi: 10.1002/art.1780180511. Arthritis Rheum. 1975. PMID: 127587
-
Tilorone and related bis-basic substituted polycyclic aromatic and heteroaromatic compounds.Prog Med Chem. 1981;18:135-90. doi: 10.1016/s0079-6468(08)70319-9. Prog Med Chem. 1981. PMID: 7045982 Review. No abstract available.
-
The biological activity of the synthetic polyanion, pyran copolymer (diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: clinical and laboratory effects of these agents as modulators of host resistance.Pharmacol Ther. 1981;15(1):1-44. doi: 10.1016/0163-7258(81)90014-0. Pharmacol Ther. 1981. PMID: 7038712 Review. No abstract available.
Cited by
-
Effect of calcitonin on different inflammatory models.Agents Actions. 1977 Dec;7(5-6):533-8. doi: 10.1007/BF02111126. Agents Actions. 1977. PMID: 146410
-
Renal lesions induced induced by tilorone and an analog. Ultrastructure and acid phosphatase study.Am J Pathol. 1978 May;91(2):355-60. Am J Pathol. 1978. PMID: 645830 Free PMC article.
-
2,6-Di-tert-butyl-4-(2'-thenoyl)phenol(R-830): a novel nonsteroidal anti-inflammatory agent with antioxidant properties.Agents Actions. 1982 Dec;12(5-6):674-83. doi: 10.1007/BF01965078. Agents Actions. 1982. PMID: 6819772
-
[The regulation of acute inflammatory processes by systemic changes of plasma protein profiles].Naturwissenschaften. 1977 Sep;64(9):471-8. doi: 10.1007/BF00446258. Naturwissenschaften. 1977. PMID: 917121 German.
-
The Arthus reaction in rats, a possible test for anti-inflammatory and antiheumatic drugs.Agents Actions. 1979 Jun;9(2):184-9. doi: 10.1007/BF02024732. Agents Actions. 1979. PMID: 157676
MeSH terms
Substances
LinkOut - more resources
Full Text Sources