Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1976 Jan 28;31(1):121-5.
doi: 10.1007/BF00270409.

Centric fission of chromosome no. 4 in the mother of two patients with trisomy 4p

B Dallapiccola, P Mastroiacovo, E Gandini
Case Reports

Centric fission of chromosome no. 4 in the mother of two patients with trisomy 4p

B Dallapiccola et al. Hum Genet. .

Abstract

Centric fission of chromosome No. 4 was found in the healthy mother of two children with trisomy 4p. The two telocentrics derived are stable and show no evidence of fusing again. The 2:3 ratio of unbalanced offsprings born to the proposita indicates that, contrary to the evidence emerging from studies in other species, the risk for the production of unbalanced gametes is high.

PubMed Disclaimer

References

    1. Science. 1972 Aug 18;177(4049):611-3 - PubMed
    1. Chromosoma. 1963;13:515-20 - PubMed
    1. Hum Hered. 1972;22(5):423-9 - PubMed
    1. Hereditas. 1970;66(1):145-52 - PubMed
    1. Humangenetik. 1975;26(3):251-5 - PubMed

Publication types

Substances