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Clinical Trial
. 2003 Jan;14(1):74-7.
doi: 10.1093/annonc/mdg003.

Results of interval debulking surgery in advanced stage ovarian cancer: an exposed-non-exposed study

P Morice  1 , D Brehier-Ollive, A Rey, D Atallah, C Lhommé, P Pautier, C Pomel, S Camatte, P Duvillard, D Castaigne
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Free article
Clinical Trial

Results of interval debulking surgery in advanced stage ovarian cancer: an exposed-non-exposed study

P Morice et al. Ann Oncol. 2003 Jan.
Free article

Abstract

Background: To study the results of interval debulking surgery (IDS) in patients treated for 'unresectable' advanced stage ovarian cancer compared with primary debulking surgery (PDS) followed by chemotherapy.

Patients and methods: An exposed-non-exposed study including a group of 34 patients who underwent an IDS and were matched to an historic control group of 34 patients treated with PDS.

Results: Optimal cytoreductive surgery was achieved in 94% (32 out of 34) of patients in both groups. The rates of post-operative morbidity, blood transfusion and median length of hospitalisation were significantly reduced in the study (IDS) group, but survival did not differ in both groups.

Conclusions: IDS in patients with advanced stage ovarian cancer offers the same chance of survival as PDS, but it is better tolerated.

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