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Review
. 2002 Dec;31(4):945-58.
doi: 10.1016/s0889-8553(02)00058-4.

Hypermethylation pathways to colorectal cancer. Implications for prevention and detection

James G Herman  1
Affiliations
Review

Hypermethylation pathways to colorectal cancer. Implications for prevention and detection

James G Herman. Gastroenterol Clin North Am. 2002 Dec.

Abstract

Epigenetic changes play an important role in the development and progression of colorectal cancer. The best characterized of these changes is the promoter region methylation of CpG islands of genes that play key roles in this disease. These changes compliment and lead to genetic changes that are well established as central to colorectal cancer progression. They may also prove useful in molecular detection approaches.

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