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. 1976 Feb 25;251(4):1188-96.

Modification of the epidermal growth factor affecting the stability of its high molecular weight complex

A C Server, A Sutter, E M Shooter
  • PMID: 1249071

Modification of the epidermal growth factor affecting the stability of its high molecular weight complex

A C Server et al. J Biol Chem. .

Abstract

The epidermal growth factor (EGF) can be isolated from the submaxillary gland of the adult male mouse as part of a high molecular weight complex (HMW-EGF). This complex can be reversibly dissociated into its subunits, EGF AND EGF-binding protein, an arginine esteropeptidase (Taylor, J. M., Cohen, S., and Mitchell, W. M. (1970) Proc. Natl. Acad. Sci. U. S. A. 67, 164-171). The COOH-terminal arginine residue of EGF was quantitatively removed by digestion with carboxypeptidase B...

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