First bite
Abstract
Dipeptidyl peptidase IV contributes to the regulation of many physiological processes, most notably blood sugar homeostasis, by biting a dipeptide off the N terminus of specific peptides. A structure of this peptidase in complex with an inhibitor will assist efforts to regulate this regulator.
Comment on
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Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog.Nat Struct Biol. 2003 Jan;10(1):19-25. doi: 10.1038/nsb882. Nat Struct Biol. 2003. PMID: 12483204