Comment
doi: 10.1038/nsb0103-6.
Getting to the heart of a splicing enhancer
- PMID: 12490885
- DOI: 10.1038/nsb0103-6
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Comment
Getting to the heart of a splicing enhancer
Nat Struct Biol.
2003 Jan.
Abstract
Dinucleotide CA repeats of variable length in an intron of the human endothelial nitric oxide synthase gene act as regulatory signals for splicing of the gene's pre-mRNA. Repeat length-dependent binding of hnRNP L to the repeats provides an intriguing link between splicing efficiency, nitric oxide synthesis and cardiovascular disease.
Comment on
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HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats.Nat Struct Biol. 2003 Jan;10(1):33-7. doi: 10.1038/nsb875. Nat Struct Biol. 2003. PMID: 12447348