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. 2002 Nov;67(11):1271-5.
doi: 10.1023/a:1021357506703.

Ionol (BHT) produces superoxide anion

E G Smirnova  1 , Yu I Lyubimov, T G Malinina, E Yu Lyubimova, N I Alexandrushkina, B F Vanyushin, G M Kolesova, L S Yaguzhinsky
Affiliations

Ionol (BHT) produces superoxide anion

E G Smirnova et al. Biochemistry (Mosc). 2002 Nov.

Abstract

In aqueous medium etiolated wheat seedlings release superoxide anion (O2*-). Interaction of a synthetic antioxidant, butylated hydroxytoluene (BHT, ionol), with oxygen in the aqueous medium is accompanied by O2*- formation. This suggests that under certain conditions BHT behaves as a prooxidant. A natural antioxidant, superoxide dismutase (SOD), and also a wound healing preparation, emulsified denatured placenta (EDP), do not exhibit the prooxidant properties. In contrast to BHT, they reduce O2*- production by the etiolated wheat seedling system.

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