IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation
- PMID: 12495721
- DOI: 10.1016/s1471-4906(02)00013-3
IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation
Abstract
The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors "keep watch" for both endogenous and exogenous molecules that indicate tissue inquiry, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.
Comment in
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IL-6, monocyte infiltration and parenchymal cells.Trends Immunol. 2003 Jun;24(6):299-300; author reply 300-1. doi: 10.1016/s1471-4906(03)00112-1. Trends Immunol. 2003. PMID: 12810103 No abstract available.
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