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. 2003 Jan 17;72(9):1001-14.
doi: 10.1016/s0024-3205(02)02349-4.

Hormonal changes during 17 days of head-down bed-rest

Marc-Antoine Custaud  1 , Sara B Arnaud, Timothy H Monk, Bruno Claustrat, Claude Gharib, Guillemette Gauquelin-Koch
Collaborators, Affiliations

Hormonal changes during 17 days of head-down bed-rest

Marc-Antoine Custaud et al. Life Sci. .

Abstract

We investigated in six men the impact of 17 days of head-down bed rest (HDBR) on the daily rhythms of the hormones involved in hydroelectrolytic regulation. This HDBR study was designed to mimic a real space flight. Urine samples were collected at each voiding before, during and after HDBR. Urinary excretion of Growth Hormone (GH), Cortisol, 6 Sulfatoxymelatonin, Normetadrenaline (NMN) and Metadrenaline (NM) was determined. A decrease in urinary cortisol excretion during the night of HDBR was noted. For GH, a rhythm was found before and during HDBR. The rhythm of melatonin, evaluated with the urine excretion of 6 Sulfatoxymelatonin (aMT6S), the main hepatic metabolite, persisted throughout the experiment without any modification to the level of phase. A decrease during the night was noted for normetadrenaline urinary derivates, but only during the HDBR.

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