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. 2002 Dec;83(6):3079-87.
doi: 10.1016/s0006-3495(02)75312-5.

The nuclear pore complex mystery and anomalous diffusion in reversible gels

Thomas Bickel  1 , Robijn Bruinsma
Affiliations

The nuclear pore complex mystery and anomalous diffusion in reversible gels

Thomas Bickel et al. Biophys J. 2002 Dec.

Abstract

The exchange of macromolecules between the cytoplasm and the nucleus of eukaryotic cells takes place through the nuclear pore complex (NPC), which contains a selective permeability barrier. Experiments on the physical properties of this barrier appear to be in conflict with current physical understanding of the rheology of reversible gels. This paper proposes that the NPC gel is anomalous and characterized by connectivity fluctuations. It develops a simplified model to demonstrate the possibility of enhanced diffusion constants of macromolecules trapped in such a gel.

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References

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