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. 2002 Dec;8(12):1409-14.
doi: 10.3201/eid0812.0200770.

Antimicrobial resistance of Escherichia coli O26, O103, O111, O128, and O145 from animals and humans

Carl M Schroeder  1 , Jianghong Meng, Shaohua Zhao, Chitrita DebRoy, Jocelyn Torcolini, Cuiwei Zhao, Patrick F McDermott, David D Wagner, Robert D Walker, David G White
Affiliations

Antimicrobial resistance of Escherichia coli O26, O103, O111, O128, and O145 from animals and humans

Carl M Schroeder et al. Emerg Infect Dis. 2002 Dec.

Abstract

Susceptibilities to fourteen antimicrobial agents important in clinical medicine and agriculture were determined for 752 Escherichia coli isolates of serotypes O26, O103, O111, O128, and O145. Strains of these serotypes may cause urinary tract and enteric infections in humans and have been implicated in infections with Shiga toxin-producing E. coli (STEC). Approximately 50% of the 137 isolates from humans were resistant to ampicillin, sulfamethoxazole, cephalothin, tetracycline, or streptomycin, and approximately 25% were resistant to chloramphenicol, trimethoprim-sulfamethoxazole, or amoxicillin-clavulanic acid. Approximately 50% of the 534 isolates from food animals were resistant to sulfamethoxazole, tetracycline, or streptomycin. Of 195 isolates with STEC-related virulence genes, approximately 40% were resistant to sulfamethoxazole, tetracycline, or streptomycin. Findings from this study suggest antimicrobial resistance is widespread among E. coli O26, O103, O111, O128, and O145 inhabiting humans and food animals.

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Figures

Figure 1
Figure 1
Comparison of antimicrobial resistance frequencies for Escherichia coli isolates from different sources. Am, ampicillin; Cx, cefoxitin; C, chloramphenicol; Frx, ceftriaxone; Smx, sulfamethoxazole; Cf, cephalothin; Gm, gentamicin; NA, nalidixic acid; Cip, ciprofloxacin; Fur, ceftiofur; Te, tetracycline; T/S, trimethoprim-sulfamethoxazole; A/C, amoxicillin-clavulanic acid; Str, streptomycin.
Figure 2
Figure 2
Comparison of antimicrobial resistance frequencies between Shiga toxin–producing Escherichia coli (STEC) and other E. coli. Of isolates from cattle, resistance frequencies were similar between STEC and other E. coli (A). In contrast, of isolates from humans, resistance frequencies were generally lower for STEC compared with other E. coli (B). Am, ampicillin; Cx, cefoxitin; C, chloramphenicol; Frx, ceftriaxone; Smx, sulfamethoxazole; Cf, cephalothin; Gm, gentamicin; NA, nalidixic acid; Cip, ciprofloxacin; Fur, ceftiofur; Te, tetracycline; T/S, trimethoprim-sulfamethoxazole; A/C, amoxicillin-clavulanic acid; Str, streptomycin.
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